Busch Lab

Team

Elisabeth Busch-Nentwich

Elisabeth Busch-Nentwich
elisabeth@buschlab.org

Elisabeth is Associate Principal Investigator in the Department of Medicine, University of Cambridge. After studying Biochemistry at the Eberhard Karls University in Tübingen Elisabeth did her PhD at the Max Planck Institute for Developmental Biology. There she participated in one of the large-scale forward genetic screens in zebrafish. In 2003 Elisabeth joined Derek Stemple’s group at the Wellcome Sanger Institute to study a group of motility mutants from the Tübingen screen. In 2005 she became project leader in the Zebrafish Mutation Project where she developed high-throughput approaches to tie morphological and molecular phenotypes to the mutations identified by exome sequencing.

Munise Merteroglu

Munise Merteroglu
munise@buschlab.org

Munise is a research assistant in the Busch Lab. She graduated from the University of Cambridge with a BA in Natural Sciences and joined the Busch Lab in 2019.

Ian Sealy

Ian Sealy
ian@buschlab.org

Ian is a bioinformatician in the Busch Lab and has a PhD in molecular biology from the University of Bristol.

He worked for seven years as a full stack web developer at the Institute for Learning & Research Technology, specialising in producing accessible and usable web applications with open source tools. He also worked for three years as Head of Technology at The Local, a European news organisation which, at the time he left, received over 3 million visitors and 25 million page views per month. Ian also worked for 20 years as a sessional lecturer at Birkbeck, University of London, where he taught a part-time Postgraduate Certificate in Web Design and Development.

Ian joined the Wellcome Sanger Institute in 2004 to work on a number of projects related to the sequencing, assembly, annotation and mutagenesis of the zebrafish genome, including ZF-MODELS and Ensembl. In 2010 he joined the Zebrafish Mutation Project and since then has worked on a range of projects, most of which are linked by their use of next-generation sequencing to analyse vertebrate gene expression.

Richard White

Richard White
rich@buschlab.org

Richard is a bioinformatician in the Busch Lab and has a PhD in developmental biology from the University of London.

He then did a postdoc for five years at the University of California, Irvine in the lab of Tom Schilling, working on retinoic acid (RA) signalling in early anterior-posterior patterning. The project focused on how degradation of RA by CYP26 enzymes affects the dynamics and robustness of RA signalling and involved a collaboration to build a mathematical model of the RA gradient.

Richard joined Derek Stemple's lab at the Wellcome Sanger Institute in 2007 to work on a project to try and infer gene regulatory relationships from gene expression data coupled with gene perturbations. In 2011, he made the switch from wet lab to bioinformatics and joined the Zebrafish Mutation Project to do variant calling from exome sequencing in order to identify mutants. Since then, Richard has worked on software to automate CRISPR/Cas9 experiments (guide RNA design and amplicon screening for variant identification) and large scale RNA-seq studies on early zebrafish and mouse development.